October 2015

Mayeta Clark 2015

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model

October 27, 2015

This world-first study identified that a very high proportion (80%) of P. vivax infections arise from dormant hypnozoites and sustain transmission. This study provided key evidence presented at 2017 WHO Expert Review Group Meeting demonstrating that currently available malaria control interventions will be insufficient to achieve elimination of P. vivax, highlighting the need to develop novel diagnostics and surveillance strategies.

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Strategies for understanding and reducing the Plasmodium vivax and Plasmodium ovale hypnozoite reservoir in Papua New Guinean children: a randomised placebo-controlled trial and mathematical model

October 27, 2015

Using an innovative design, this study proved that 80% of all P. vivax bloodstage infections are caused by relapses from long-lasting liverstages and using mathematical models we predicted that elimination of P. vivax will be difficult without attacking the silent hypnozoite reservoir.

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Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

October 1, 2015

Monoclonal antibodies are being developed as therapeutics to complement drugs and vaccines or to fill the gap where no drugs…

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