Structure- and function-based design of Plasmodium-selective proteasome inhibitors
February 11, 2016
The team used a revolutionary technique called Cryo-Electron Microscopy to determine the 3D structure of the malaria parasite proteasome. This enabled design of an inhibitor that is able to attenuate parasite growth in vivo without significant toxicity to the host. The compound is active against strains of the malaria parasite from South East Asia that are resistant to currently used antimalarial drugs.
Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2
February 11, 2016
MSP2 is an intrinsically disordered protein that is abundant on the merozoite surface and essential to the parasite Plasmodium falciparum….
Acquisition and longevity of antibodies to Plasmodium vivax pre-erythrocytic antigens in Western Thailand
February 1, 2016
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