Declining malaria transmission differentially impacts the maintenance of humoral immunity to Plasmodium falciparum in children
October 17, 2017
A decline in malaria transmission is associated with an overall reduction in naturally acquired immunity. However, loss of immunity is not universal; some key functional immune responses and antibodies to specific targets are better maintained and these may continue to provide some long-term protection against malaria
A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum
October 9, 2017
We demonstrated for the first time how to account for drug-accumulation effects in models of the host-response to malaria, with significant implications for our understanding of antimalarial efficacy and resistance.
A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
October 7, 2017
We introduced a mathematical model of artemisin-induced growth-retardation, validated against short drug pulse in vitro experiments of drug action. Combined with new models of drug-accumulation effects, this work provides a key element for improved PK-PD models for malaria.
Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development
October 6, 2017
The sexual stages of P. falciparum adopt a unique crescent shape that is essential for transmission via mosquitoes. We provide 3D views of the elongating parasite at unprecedented resolution. Inducible genetic disruption reveals proteins that are essential for gametocyte elongation and survival. This work points to potential targets for the development of transmission-blocking therapies.