A fluorometric assay to determine the protective effect of glucose-6-phosphate dehydrogenase (G6PD) against a Plasmodium spp. infection in females heterozygous for the G6PD gene: proof of concept in Plasmodium falciparum
February 22, 2022
Objective: Glucose-6-phosphate dehydrogenase (G6PD) deficiency offers some protection against malaria; however, the degree of protection is poorly described and likely…
Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development
February 15, 2022
The emergence and spread of parasite resistance to currently available antimalarials has highlighted the importance of developing novel antimalarials. This…
Global diversity and balancing selection of 23 leading Plasmodium falciparum candidate vaccine antigens
February 2, 2022
Investigation of the diversity of malaria parasite antigens can help prioritize and validate them as vaccine candidates and identify the…
Tafenoquine for children: a step towards implementation
February 1, 2022
After several decades of development, tafenoquine, an 8-aminoquinoline compound, was registered by the US Food and Drug Administration on July…
Spatial codistribution of HIV, tuberculosis and malaria in Ethiopia
February 1, 2022
Background: HIV, tuberculosis (TB) and malaria are the three most important infectious diseases in Ethiopia, and sub-Saharan Africa. Understanding the…