Targeting malaria parasites with novel derivatives of azithromycin
November 30, 2022
Introduction: The spread of artemisinin resistant Plasmodium falciparum parasites is of global concern and highlights the need to identify new antimalarials for future…
Quantification of Tafenoquine and 5,6-Orthoquinone Tafenoquine by UHPLC-MS/MS in Blood, Plasma, and Urine, and Application to a Pharmacokinetic Study
November 24, 2022
Analytical methods for the quantification of the new 8-aminoquinoline antimalarial tafenoquine (TQ) in human blood, plasma and urine, and the…
Pathogenicity and virulence of malaria: sticky problems and tricky solutions
November 23, 2022
Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths each year, concentrated in Africa and in young children,…
Longitudinal IgG antibody responses to Plasmodium vivax blood-stage antigens during and after acute vivax malaria in individuals living in the Brazilian Amazon
November 23, 2022
Background: To make progress towards malaria elimination, a highly effective vaccine targeting Plasmodium vivax is urgently needed. Evaluating the kinetics…
The RTS,S malaria vaccine: Current impact and foundation for the future
November 16, 2022
The RTS,S vaccine has recently been recommended for implementation as a childhood vaccine in regions with moderate-to-high malaria transmission. We…
Eotaxin-2 and eotaxin-3 in malaria exposure and pregnancy
November 15, 2022
Background: Eotaxin-1 concentrations in plasma have been inversely associated with malaria exposure, malaria infection and pregnancy, but the effect of…
Effect of out-of-village working activities on recent malaria exposure in the Peruvian Amazon using parametric g-formula
November 9, 2022
In the Amazon Region of Peru, occupational activities are important drivers of human mobility and may increase the individual risk…