October 12, 2022
Evaluation of a pharmacokinetic-pharmacodynamic model for predicting parasitological outcomes in Phase 2 studies of new antimalarial drugs with Professor Julie Simpson
The unrelenting rise of multidrug resistant malaria demands the continuous development of novel antimalarial compounds from preclinical studies in human volunteers to Phase 3 clinical trials in patients. This presentation will present a simulation study performed to assess the utility of a Bayesian hierarchical mechanistic pharmacokinetic-pharmacodynamic(PK-PD) model for predicting parasite-time profiles for a Phase 2 study of a new antimalarial drug, cipargamin.
Professor Julie Simpson, Professor and Director of Health Clinical Research, Melbourne School of Population and Global Health
Professor Simpson is Head of the Biostatistics Unit at the Melbourne School of Population and Global Health, Director of the Methods and Implementation Support for Clinical and Health (MISCH) Research Hub, and recipient of a NHMRC Leadership Investigator Grant (2021-5).
The cost-effectiveness of tafenoquine following G6PD screening in Brazil: a transmission model analysis with Dr Angela Devine
While results from a Plasmodium vivax dynamic model have shown the potential impact of quantitative glucose-6-phosphate dehydrogenase (G6PD) test-and-treat strategies using tafenoquine for radical cure on cases averted, the cost-effectiveness has not been previous explored using a transmission model framework. Here, we explore the impact on the overall cost-effectiveness in Brazil under four scenarios. Our results provide strong evidence that tafenoquine prescribed after a quantitative G6PD test is highly likely to be cost-effective in Brazil.
Dr Angela Devine, Senior Research Fellow and Lecturer in Public Health
Angela Devine is a health economist with over 10 years of experience in the economic evaluation and costs related to the management of infectious diseases. She leads the Health Economics Group at Menzies and is a Global Gender Equality in Health Leadership Committee Member for Women in Global Health (WGH) Australia. Since joining Menzies in 2018, she has helped to secure over $12 million in grant funding.