Prof. James Beeson is Deputy Director at the Burnet Institute, and Head of the Malaria Immunity and Vaccine Group, and an adjunct professor at Monash University (Deputy Director (People); Head of Malaria Immunity and Vaccines Laboratory; Adjunct Professor Monash University). James is a public health physician and has worked in malaria research in South East Asia and East Africa for many years. A major focus of his research is aimed at understanding the targets and mechanisms of protective immunity in humans, and using this knowledge to advance vaccine development and evaluation. He is also involved in evaluating and strengthening strategies for malaria control, approaches to enhance malaria surveillance, and operational research in Papua New Guinea. At ACREME, James and his group will i) develop and evaluate malaria sero-surveillance approaches, including the development and evaluation of simple low-cost point-of-contact devices for field applications, ii) evaluate health services and malaria treatment and prevention in Papua New Guinea, iii) determine the impact of changes in malaria epidemiology on malaria immunity and risk, and iv) evaluate immunity induced by vaccines and identify correlates of protection.Related Projects
- Access and adherence to malaria interventions
- Epidemiological modelling for malaria elimination
- Identifying “hot spots” and “hot pops” with serological surveillance and operational research of high sensitivity tests
- Identifying populations at risk of multidrug resistant malaria
- Impact of declining transmission on malaria treatment outcomes, immunity and risk of rebound
- Malaria vaccine development and evaluation
- Operational research on access and coverage of malaria interventions
- Pregnant women and malaria surveillance
- Rapid point-of contact test for malaria surveillance based on serology
Related Publications
- Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children
- Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
- Antibody targets on the surface of Plasmodium falciparum-infected erythrocytes that are associated with immunity to severe malaria in young children
- Asia-Pacific ICEMR: Understanding Malaria Transmission to Accelerate Malaria Elimination in the Asia Pacific Region
- Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate-high malaria transmission intensity
- Community-based molecular and serological surveillance of subclinical malaria in Myanmar
- Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
- Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives
- Declining malaria transmission differentially impacts the maintenance of humoral immunity to Plasmodium falciparum in children
- Declining transmission and immunity to malaria and emerging artemisinin resistance in Thailand: a longitudinal study
- Decreasing malaria prevalence and its potential consequences for immunity in pregnant women
- Defining species-specific and conserved interactions of apical membrane protein 1 during erythrocyte invasion in malaria to inform multi-species vaccines
- Effectiveness of repellent delivered through village health volunteers on malaria incidence in villages in South-East Myanmar: a stepped-wedge cluster-randomised controlled trial protocol
- Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial
- Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort
- Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children
- Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against clinical malaria
- Identification and prioritization of merozoite antigens as targets of protective human immunity to falciparum malaria for vaccine and biomarker development
- Identifying and combating the impacts of COVID-19 on malaria
- Immunological markers of vivax exposure and immunity: A Systematic Review and Meta-analysis
- Impact of Environmental Modifications on the Ecology, Epidemiology, and Pathogenesis of Plasmodium falciparum and Plasmodium vivax Malaria in East Africa
- Induction and decay of functional complement-fixing antibodies by the RTS,S malaria vaccine in children, and a negative impact of malaria exposure
- Induction, decay and determinants of functional antibodies following vaccination with the RTS,S malaria vaccine in young children
- Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial
- Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study
- Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia
- Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
- Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases
- Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial
- Multiple morbidities in pregnancy: Time for research, innovation, and action
- Opsonic phagocytosis of Plasmodium falciparum merozoites: mechanism in human immunity and a correlate of protection against malaria
- Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures
- Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women
- Strain-transcending immune response generated by chimeras of the malaria vaccine candidate merozoite surface protein 2
- Targeting malaria parasites with novel derivatives of azithromycin
- Targets of complement-fixing antibodies in protective immunity against malaria in children
- The complex relationship of exposure to new Plasmodium infections and clinical incidence in PNG
- The direct binding of Plasmodium vivax AMA1 to erythrocytes defines a RON2-independent invasion pathway
- The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children
- The relationship between anti-merozoite antibodies and incidence of P. falciparum malaria: A systematic review and meta-analysis.
- The RTS,S malaria vaccine: Current impact and foundation for the future