Professor Julie Simpson is Head of Biostatistics and Deputy Head of the Melbourne School of Population and Global Health at the University of Melbourne, and leader of the biostatistics node of the Melbourne Clinical and Translational Sciences Platform. She was awarded a NHMRC Senior Research Fellowship (2016-20). Her primary area of research is the bridging of novel statistical and mathematical modelling approaches to inform treatment policy for malaria and she has been an advisor to WHO, Medicines for Malaria Venture and the WorldWide Antimalarial Resistance Network regarding dosing regimens for current and new antimalarial drugs.Related Projects
- Development of Novel Antimalarial Drugs that Target Proteostasis
- Epidemiological modelling for malaria elimination
- Evaluation and prediction of the effect of combinations of antimalarial drugs
- Identifying better treatments for uncomplicated malaria
- Impact of declining transmission on malaria treatment outcomes, immunity and risk of rebound
- Malaria vaccine development and evaluation
- Rapid point-of contact test for malaria surveillance based on serology
- Understanding kinetics of antigens used in rapid diagnostic tests for malaria
- Within-host malaria modelling to improve the treatment of malaria
Related Publications
- A dynamic stress model explains the delayed drug effect in artemisinin treatment of Plasmodium falciparum
- A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection
- Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
- An artesunate pharmacometric model to explain therapeutic responses in falciparum malaria
- Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study
- Antibody targets on the surface of Plasmodium falciparum-infected erythrocytes that are associated with immunity to severe malaria in young children
- Antibody to Plasmodium falciparum variant surface antigens, var gene transcription and ABO blood group in children with severe or uncomplicated malaria
- Characterizing antibody responses to mosquito salivary antigens of the Southeast Asian vectors of malaria and dengue with a human challenge model of controlled exposure: a protocol
- Community-based molecular and serological surveillance of subclinical malaria in Myanmar
- Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia
- Contribution of Functional Antimalarial Immunity to Measures of Parasite Clearance in Therapeutic Efficacy Studies of Artemisinin Derivatives
- Cost-Effectiveness Analysis of Sex-Stratified Plasmodium vivax Treatment Strategies Using Available G6PD Diagnostics to Accelerate Access to Radical Cure
- Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting
- Declining transmission and immunity to malaria and emerging artemisinin resistance in Thailand: a longitudinal study
- Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria
- Early and late mortality after malaria in young children in Papua, Indonesia
- Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study
- Evaluation of the effectiveness of topical repellent distributed by village health volunteer networks against Plasmodium spp. infection in Myanmar: A stepped-wedge cluster randomised trial
- Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study
- Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort
- Identifying and combating the impacts of COVID-19 on malaria
- Immunological markers of vivax exposure and immunity: A Systematic Review and Meta-analysis
- Implications of population-level immunity for the emergence of artemisinin-resistant malaria: a mathematical model.
- In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance
- Intermittent screening and treatment for malaria complementary to routine immunisation in the first year of life in Papua, Indonesia: a cluster randomised superiority trial
- Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies
- Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) for treating Plasmodium falciparum malaria patients using mathematical modelling
- Iron deficiency during pregnancy is associated with a reduced risk of adverse birth outcomes in a malaria-endemic area in a longitudinal cohort study
- Longitudinal trends in malaria testing rates in the face of elimination in eastern Myanmar: a 7-year observational study
- Major burden of severe anemia from non-falciparum malaria species in southern Papua: A hospital-based surveillance study
- Making the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugs
- Malaria morbidity and mortality following introduction of a universal policy of artemisinin-based treatment for malaria in Papua, Indonesia: A longitudinal surveillance study
- Mechanistic Modeling of Primaquine Pharmacokinetics, Gametocytocidal Activity, and Mosquito Infectivity
- Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection
- Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium Vivax Volunteer Infection Study
- Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review
- Quantification of parasite clearance in Plasmodium knowlesi infections
- Quantification of the dynamics of antibody response to malaria to inform sero-surveillance in pregnant women
- Quantifying the association between malaria in pregnancy and stillbirth: A systematic review and meta-analysis
- Reducing the risk of Plasmodium vivax after falciparum infections in co-endemic areas – a radomised controlled trial
- Risk of Plasmodium vivax parasitaemia after Plasmodium falciparum infection: a systematic review and meta-analysis.
- Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia.
- Scoping Review of Antimalarial Drug Candidates in Phase I and II Drug Development
- Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria
- Severe malaria, Pascalian therapeutics and the US FDA
- Short-course primaquine for the radical cure of Plasmodium vivax malaria: a multicentre, randomised, placebo-controlled non-inferiority trial
- Supervised versus unsupervised primaquine radical cure for the treatment of falciparum and vivax malaria in Papua, Indonesia: a cluster-randomised, controlled, open-label superiority trial
- Surveillance to achieve malaria elimination in eastern Myanmar: a 7-year observational study
- Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
- The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis
- The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis
- The effect of chloroquine dose and primaquine on Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient pooled meta-analysis
- The efficacy of dihydroartemisininpiperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis
- The haematological consequences of Plasmodium vivax malaria after chloroquine treatment with and without primaquine: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
- The heterogeneity of symptom reporting across study sites: a secondary analysis of a randomised placebo-controlled multicentre antimalarial trial
- The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial.
- The relationship between anti-merozoite antibodies and incidence of P. falciparum malaria: A systematic review and meta-analysis.
- The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study
- The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
- Unsupervised primaquine for the treatment of Plasmodium vivax malaria relapses in southern Papua: a hospital-based cohort study
- Variation in Glucose-6-Phosphate Dehydrogenase activity following acute malaria
- Within-host modeling of blood-stage malaria