The RTS,S malaria vaccine: Current impact and foundation for the future

Published: November 16, 2022

Citation

Beeson JG, Kurtovic L, Valim C, Asante KP, Boyle MJ, Mathanga D, Dobano C, Moncunill G. The RTS,S malaria vaccine: Current impact and foundation for the future. Science Translational Medicine. 2022 Nov 16; 671(14). DOI: 10.1126/scitranslmed.abo6646.

Abstract

The RTS,S vaccine has recently been recommended for implementation as a childhood vaccine in regions with moderate-to-high malaria transmission. We discuss mechanisms of vaccine protection and longevity, implementation considerations, and future research needed to increase the vaccine’s health impact, including vaccine modifications for higher efficacy and longevity of protection.

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