Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria
June 29, 2021
Background: Plasmodium falciparum causes placental malaria, which results in adverse outcomes for mother and child. P. falciparum-infected erythrocytes that express the parasite protein…
Seeking an optimal dosing regimen for OZ439/DSM265 combination therapy for treating uncomplicated falciparum malaria
June 28, 2021
Background: The efficacy of artemisinin-based combination therapies (ACTs), the first-line treatments for uncomplicated falciparum malaria, has been declining in malaria-endemic countries…
Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study
June 1, 2021
Background: In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America, and…
Community-based molecular and serological surveillance of subclinical malaria in Myanmar
May 28, 2021
Background In the Greater Mekong Subregion (GMS), current malaria surveillance strategies rely on a network of village health volunteers (VHVs)…
Glucose-6-phosphate dehydrogenase activity in individuals with and without malaria: Analysis of clinical trial, cross-sectional and case-control data from Bangladesh
April 23, 2021
Background Glucose-6-phosphate dehydrogenase (G6PD) activity is dependent upon G6PD genotype and age of the red blood cell (RBC) population, with…
The changing epidemiology of Plasmodium vivax: Insights from conventional and novel surveillance tools
April 23, 2021
Sarah Auburn and co-authors discuss the unique biology and epidemiology of P. vivax and current evidence on conventional and new…
Estimated impact of tafenoquine for Plasmodium vivax control and elimination in Brazil: A modelling study
April 23, 2021
Background Despite recent intensification of control measures, Plasmodium vivax poses a major challenge for malaria elimination efforts. Liver-stage hypnozoite parasites that cause…
Optimizing Myanmar’s community-delivered malaria volunteer model: a qualitative study of stakeholders’ perspectives
February 8, 2021
Background In parallel with the change of malaria policy from control to elimination and declines in the malaria burden in…
The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network
November 19, 2020
Background There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk…
Monitoring Plasmodium falciparum and Plasmodium vivax using microsatellite markers indicates limited changes in population structure after substantial transmission decline in Papua New Guinea
September 28, 2020
Monitoring the genetic structure of pathogen populations may be an economical and sensitive approach to quantify the impact of control…