Quantification of glucose-6-phosphate dehydrogenase activity by spectrophotometry: A systematic review and meta-analysis
May 14, 2020
Background The radical cure of Plasmodium vivax and P. ovale requires treatment with primaquine or tafenoquine to clear dormant liver stages. Either drug can induce…
Cost-Effectiveness Analysis of Sex-Stratified Plasmodium vivax Treatment Strategies Using Available G6PD Diagnostics to Accelerate Access to Radical Cure
May 4, 2020
Tafenoquine has been licensed for the single-dose radical cure of Plasmodium vivax in adults; however, it is only recommended in patients with…
Multifunctional Antibodies Are Induced by the RTS,S Malaria Vaccine and Associated With Protection in a Phase 1/2a Trial
March 31, 2020
This study evaluated functional antibody responses in clinical trials of RTS,S and demonstrated for the first time that vaccination with RTS,S induces antibodies that function to recruit complement and activate specialised immune cells against malaria.
The risk of morbidity and mortality following recurrent malaria in Papua, Indonesia: a retrospective cohort study
February 20, 2020
Background An acute episode of malaria can be followed by multiple recurrent episodes either due to re-infection, recrudescence of a…
Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency
February 10, 2020
Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study
January 29, 2020
Background: In endemic regions, the age distribution of malaria varies according to the infecting Plasmodium species. We aimed to delineate the…
Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review
January 16, 2020
Background In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells…
Dealing with indeterminate outcomes in antimalarial drug efficacy trials: a comparison between complete case analysis, multiple imputation and inverse probability weighting
November 27, 2019
Background Antimalarial clinical efficacy studies for uncomplicated Plasmodium falciparum malaria frequently encounter situations in which molecular genotyping is unable to…
Protective Immunity against Severe Malaria in Children Is Associated with a Limited Repertoire of Antibodies to Conserved PfEMP1 Variants
November 13, 2019
Extreme diversity of the major Plasmodium falciparum antigen, PfEMP1, poses a barrier to identifying targets of immunity to malaria. Here, we used…
Early and late mortality after malaria in young children in Papua, Indonesia
October 30, 2019
Background In southern Papua, Indonesia, malaria is highly prevalent in young children and is a significant cause of morbidity and…