Understanding patterns of antigen diversity and immune selection pressure amongst leading Plasmodium vivax vaccine candidates and serosurveillance markers

October 26, 2022


Paolo completed a comprehensive meta-population genetic analysis of the diversity and immune selection hotspots of the leading Plasmodium vivax antigen candidate genes and sero-surveillance markers. He measured patterns of genetic diversity and selection pressure using traditional population genetics, Tajima’s D, haplotype network analysis, and structural bioinformatics. Information gathered from his study will guide researchers on the rational selection of antigen gene constructs to be included in designing a widely effective vaccine against Plasmodium vivax

Paolo Bareng, PhD Student, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University and the Centre for Innovation in Infectious Diseases and Immunology Research (CIIDIR)